Sleep Genetics
Your genome.
Decoded for sleep.
90 genetic variants across 10 sleep-relevant pathways — from circadian clocks to glymphatic clearance, mapped to the neuroscience that matters.
Works with data from
Get Started
Three steps to your sleep profile
Upload your DNA
Drop your raw data file from 23andMe or AncestryDNA. Processing takes about 30 seconds.
Get your sleep profile
We analyze ~90 variants across circadian clocks, neurotransmitters, stress axes, and repair pathways.
See the evidence
Every finding comes with evidence grading, reference counts, and replication status. No hand-waving.
10 Pathways
Sleep is not one thing
From the molecular clock to the glymphatic night shift, we map your genome to the systems that actually control how you sleep.
The Molecular Clock
9 variants — Core circadian oscillator and melatonin output pathway.
The Flip-Flop Switch
8 variants — Sleep-wake neurocircuitry β mutual inhibition between VLPO sleep neurons and arousal centers.
Caffeine & Alertness
5 variants — How you metabolize caffeine, and your baseline dopaminergic alertness.
The Monoamine Orchestra
12 variants — Serotonin, dopamine, norepinephrine β the neurotransmitters that sculpt sleep architecture, mood, and memory consolidation.
The Stress Axis
7 variants — HPA axis dynamics, cortisol regulation, and stress resilience β how stress dismantles your sleep.
The Glymphatic Night Shift
11 variants — Brain waste clearance, somnogenic cytokines, and antioxidant defense β what your brain does while youβre unconscious.
The Feeding Clock
10 variants — Appetite hormones, insulin signaling, and thermogenesis β the sleep-metabolism crosstalk that explains why bad sleep makes you hungry.
The Cofactor Pipeline
12 variants — B-vitamins, methylation, and BH4 β the upstream supply chain for synthesizing melatonin, serotonin, and dopamine.
The Endocrine Tempo
6 variants — Thyroid function and sex hormones β the pulsatile endocrine signals that set your circadian amplitude and sleep architecture.
The Nocturnal Repair Crew
10 variants — Telomere maintenance, sirtuins, and longevity pathways β the cellular repair program that activates while you sleep.
Metascience Layer
Built for scientists who read the methods section
Every variant shows its evidence level, reference count, and whether the finding survived replication. Because “genome-wide significant” and “blog post” are not the same thing.
Evidence grading
Established, strong, moderate, or suggestive — no false precision.
Reference counts
See how many studies support each variant. Hover for titles.
Replication status
Meta-analyses and GWAS replications flagged automatically.
Ready to decode your sleep?
Free, private, and built on the GeneOps research engine. Your data stays yours.
Get started free