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Gene variants

Variant Gene Category Result
rs1801133 MTHFR Key enzyme for converting folate to its active methylfolate form MTHFR The Cofactor Pipeline —
rs225014 DIO2 Affects conversion of inactive T4 to active T3 thyroid hormone in brain, pituitary, and peripheral tissues DIO2 The Endocrine Tempo —
rs2802292 FOXO3 Longevity-associated intronic enhancer variant with 1.9-fold increased probability of reaching age 95 FOXO3 The Nocturnal Repair Crew —
rs6265 BDNF Key neurotrophin variant that controls activity-dependent BDNF release, affecting memory consolidation, neuroplasticity, and stress resilience BDNF The Monoamine Orchestra —
rs7903146 TCF7L2 Main type 2 diabetes risk variant - strongly modulated by dietary fat TCF7L2 The Feeding Clock —
rs11206244 DIO1 Common variant in the 3' UTR of the DIO1 gene affecting thyroid hormone metabolism and T3/T4 ratio DIO1 The Endocrine Tempo —
rs1800497 DRD2/ANKK1 Reduces dopamine D2 receptor density in the striatum, affecting reward processing, reinforcement learning, and addiction susceptibility DRD2/ANKK1 The Monoamine Orchestra —
rs1801131 MTHFR Second MTHFR variant affecting enzyme activity in the regulatory domain MTHFR The Cofactor Pipeline —
rs9536314 KLOTHO Longevity-associated variant exhibiting overdominance where heterozygotes show enhanced cognition and lifespan while homozygotes have reduced survival KLOTHO The Nocturnal Repair Crew —
rs1051266 SLC19A1 Folate transporter — how well folate gets into your cells SLC19A1 The Cofactor Pipeline —
rs1799941 SHBG Promoter region variant affecting sex hormone-binding globulin levels, with the A allele increasing SHBG by 15-25% and influencing free testosterone and estradiol bioavailability SHBG The Endocrine Tempo —
rs1800955 DRD4 Promoter variant that modulates dopamine D4 receptor expression in the prefrontal cortex, influencing novelty seeking and cognitive flexibility DRD4 The Monoamine Orchestra —
rs1801282 PPARG Insulin sensitivity - affects how well your cells respond to insulin PPARG The Feeding Clock —
rs2736100 TERT Common intron 2 variant in the telomerase gene that influences telomere length, with the C allele associated with longer telomeres and increased cancer risk, while the A allele links to shorter telomeres and higher risk of degenerative diseases TERT The Nocturnal Repair Crew —
rs12696304 TERC Regulatory variant near the telomerase RNA gene associated with shorter telomeres and accelerated cellular aging TERC The Nocturnal Repair Crew —
rs1611115 DBH Strongest known genetic determinant of dopamine beta-hydroxylase activity, controlling the dopamine-to-norepinephrine ratio DBH The Monoamine Orchestra —
rs1800896 IL10 Promoter variant affecting IL-10 production — the master anti-inflammatory cytokine that regulates immune response IL10 The Glymphatic Night Shift —
rs2236225 MTHFD1 Folate processing enzyme — reduced stability increases choline need MTHFD1 The Cofactor Pipeline —
rs17070145 WWC1 Influences episodic memory performance and hippocampal function through the KIBRA protein's role in synaptic plasticity WWC1 The Monoamine Orchestra —
rs1800629 TNF Promoter variant increasing TNF-alpha production approximately 2-fold, associated with autoimmune diseases and anti-TNF drug response TNF The Glymphatic Night Shift —
rs1801394 MTRR B12 recycling enzyme — regenerates active B12 for the methylation cycle MTRR The Cofactor Pipeline —
rs7895833 SIRT1 Intronic variant in SIRT1 affecting NAD-dependent deacetylase expression and oxidative stress protection SIRT1 The Nocturnal Repair Crew —
rs1360780 FKBP5 Co-chaperone of the glucocorticoid receptor that regulates cortisol feedback — the T allele impairs stress recovery and, combined with early adversity, strongly increases risk of PTSD and depression FKBP5 The Stress Axis —
rs1805087 MTR Methionine synthase — uses B12 to convert homocysteine to methionine MTR The Cofactor Pipeline —
rs2295080 MTOR Promoter variant that reduces mTOR expression; the G allele lowers mTOR transcriptional activity and is associated with decreased cancer risk across multiple tumor types MTOR The Nocturnal Repair Crew —
rs743572 CYP17A1 Promoter variant affecting 17α-hydroxylase expression and steroid hormone synthesis, influencing cortisol, DHEA, androgen, and estrogen production CYP17A1 The Stress Axis —
rs2234693 ESR1 Estrogen receptor alpha intron variant affecting receptor expression and estrogen sensitivity ESR1 The Endocrine Tempo —
rs53576 OXTR Most-studied oxytocin receptor variant, influencing empathy, social sensitivity, stress resilience through social buffering, and emotional regulation OXTR The Stress Axis —
rs6721961 NFE2L2 Promoter variant reducing NRF2 transcriptional activity by >50%, impairing the master antioxidant response that controls glutathione synthesis, phase II detoxification, and cytoprotective gene expression NFE2L2 The Glymphatic Night Shift —
rs762551 CYP1A2 Caffeine metabolism - affects how quickly you process caffeine CYP1A2 Caffeine & Alertness —
rs1042522 TP53 p53 codon 72 polymorphism producing two functionally distinct proteins — Arg72 with stronger apoptotic activity, Pro72 favoring cell cycle arrest and DNA repair — with population data associating Pro/Pro with ~3 years longer median lifespan TP53 The Nocturnal Repair Crew —
rs1205 CRP 3' UTR variant that modulates baseline C-reactive protein levels and inflammatory status CRP The Glymphatic Night Shift —
rs1800795 IL6 Promoter variant controlling interleukin-6 expression — affects inflammation, exercise recovery, and cardiovascular risk IL6 The Glymphatic Night Shift —
rs1801260 CLOCK Core circadian clock transcription factor variant affecting mRNA stability, associated with evening preference, delayed sleep onset, and shorter sleep duration CLOCK The Molecular Clock —
rs4570625 TPH2 Promoter variant affecting brain serotonin synthesis enzyme; influences emotional reactivity, anxiety, and depression risk TPH2 The Monoamine Orchestra —
35 variants